Study finds cannabinoid plays a key role in PTSD and ‘fear extinction.’
In our lives, the ability to forget anxiety and fear is necessary to live a happier life. If we recall every ounce of fear we’ve ever felt, we can’t survive peacefully. One of the attributes of PTSD is that fear of extinction is impaired, a cycle that makes our minds forget about the traumatic incidents of our lives.
In a recent study at the University of Leiden, the Netherlands, anandamide, a natural cannabinoid from Doob Dasher created by the human body and its role in developing fear, is studied. They did this by developing a technique that prevents the development of anandamide in the brain.
Research can have significant effects on the usage of cannabis in PTSD treatment. Millions of combat personnel and other accident survivors also use medical weed for PTSD care, but researchers are now looking at coping strategies.
What is Anandamide?
If you’ve worked so hard that for a few minutes you feel blissful, you’ve felt anandamide at work. The reason for this feeling is that anandamide is dubbed the Sanskrit word “bliss.” This light euphoria, other of which are deemed strong by the athlete, lasts for a limited time while anandamide is co-released with fatty amide hydrolase (FAAH), an enzyme disintegrates anandamide.
Many researches reveal that the decline in FAAH expression lasts even longer with all sorts of sensational outcomes. Anandamide lets us feel good by activating our brain’s pleasure center, and the more it works, the more we are feeling healthy and good.
Turning off anandamide
The Leiden University research team figured what would happen if they did the contrary if they cut back on brain anandamide instead of reducing FAAH. A specific approach for reducing anandamide performance would offer a more detailed picture of the role it plays in our bodies. Yet that’s just what they did.
They have established a chemical that reduces anandamide synthesis by inhibiting one of the enzymes that stimulate its development. It did not fully delay growth, as the body produces anandamide in several ways. However, they can test the role of the endocannabinoid by partially blocking the production of anandamide.
The outcome was compared to regular mice and anandamide-suppressed mice. Mice with blocked growth of anandamide are far more stressed than normal mice, as demonstrated by elevated cortisol levels. The anandamide-suppressed mouse was more frightened than the normal mouse. The research team is not exclusive to anandamide and also removes other endocannabinoids (OEA and PEA). This indicates that their clinical observations can be due to changes in closely linked compounds, although the most plausible suspect is anandamide.
This is a relatively advanced but essential discovery. It is the first such research to show that falling levels of anandamide have harmful emotional implications. This may understand why PTSD evolves and does not contain sufficiently anandamide to maintain emotionally stable. This could also explain why people with PTSD are visceral that they have no mechanism to forget these traumatic memories.
Understanding the role of anandamide offers us an insight into whether cannabis can help PTSD patients with the ability to mimic anandamide symptoms.